Healthcare Service Development Based on Alcohol
Health Risk Indicators
Healthcare Service Development Based on Alcohol
Health Risk Indicators
We have long studied the relationship between cancer development and alcohol consumption, and have demonstrated the mechanism by which acetaldehyde related DNA damages in esophageal epithelial cells. For human application, we focused on the function of acetaldehyde dehydrogenase 2 (ALDH2) and developed a device to measure an individual's ability to metabolize ethanol by exhaled breath. It has been found that there are large differences in the ability of each individual to metabolize alcohol, even among people with the same type of genetic mutation of ALDH2. Drug development for the prevention of alcohol induced carcinogenesis through in silico docking simulation is also underway.
- Affiliation:
- Kyoto University
Graduate School of Medicine
Department of Medical Oncology
- Representative:
- Manabu Muto
Professor,
Kyoto University
Graduate School of Medicine
Department of Medical Oncology
Manabu Muto MD
After working at the National Cancer Center Hospital East, he became Associate Professor at the Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University in 2007, and Professor at the Department of Therapeutic Oncology in 2012. He specializes in gastrointestinal cancer chemotherapy and precision cancer care. He also serves in senior positions within the hospital, including Director of the Cancer Center at Kyoto University Hospital.
SOCIALSocial Implementation
Innovative Health Management Services for Offices and Workers
Alcohol is associated with more than 200 diseases, and Asians, including Japanese, are particularly susceptible to health problems due to their low ability to metabolize alcohol. In this project, (1) a large-scale database will be built based on data on individual alcohol metabolism, health checkups at workplaces, and past history of illnesses, (2) alcohol intake management tools will be developed, (3) health management services using workplace health checkups, and (4) prevention of health problems caused by acetaldehyde will be provided as services for business enterprises and their employees.
ORIGINALITYUniqueness, Passion for Development
Novel System Combines Individual Alcohol Metabolic Capacity with Health Information
WHO states that alcohol consumption is as harmful to humans as smoking. In East Asia, region-specific genetic polymorphisms (ALDH2) require an approach based on individual alcohol metabolic capacity. For example, in Taiwan, awareness of alcohol susceptibility has increased and genetic testing for ALDH2 is offered, but this is clearly different from this project, which combines health information with an individual's specific alcohol metabolic capacity. We believe that this project, which is preventive medicine stratified by level of risk, is essential for the realization of a healthy society.
VISIONDream, Outlook, Business Image
Improving the Health of the Population with a Focus on the Global Drinking Habits Management Market
WHO has recommended a 20% reduction in hazardous drinking by 2030, and in particular the need to monitor alcohol consumption. However, no tools currently exist to achieve this. Providing tools to manage drinking habits and health risks will have a positive impact on the overall health. The project will contribute to people's health by commercializing the product for the market of alcohol consumption habit management, for which there is a growing need worldwide.
